About the Authors

Alan Lopez-Lopez

Contributed equally to this work with: Alan Lopez-Lopez, Josep Gamez

Affiliations Biochemistry and Molecular Biology Unit, Department of Physiological Sciences I, Faculty of Medicine - IDIBAPS, University of Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII), Barcelona, Spain

Josep Gamez

Contributed equally to this work with: Alan Lopez-Lopez, Josep Gamez

josepgamez.bcn@gmail.com (JG); josevidal@ub.edu (JMVT)

Affiliation ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron - VHIR. Autonomous University of Barcelona, Barcelona, Spain

Emilio Syriani

Affiliations ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron - VHIR. Autonomous University of Barcelona, Barcelona, Spain, Synaptic Structural Plasticity Lab, CIBIR, Logroño, Spain

Miguel Morales

Affiliation Synaptic Structural Plasticity Lab, CIBIR, Logroño, Spain

Maria Salvado

Affiliation ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron - VHIR. Autonomous University of Barcelona, Barcelona, Spain

Manuel J. Rodríguez

Affiliations Biochemistry and Molecular Biology Unit, Department of Physiological Sciences I, Faculty of Medicine - IDIBAPS, University of Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII), Barcelona, Spain

Nicole Mahy

Affiliations Biochemistry and Molecular Biology Unit, Department of Physiological Sciences I, Faculty of Medicine - IDIBAPS, University of Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII), Barcelona, Spain

Jose M. Vidal-Taboada

josepgamez.bcn@gmail.com (JG); josevidal@ub.edu (JMVT)

Affiliations Biochemistry and Molecular Biology Unit, Department of Physiological Sciences I, Faculty of Medicine - IDIBAPS, University of Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, ISCIII), Barcelona, Spain

Competing Interests

The authors have read the journal's policy and have the following conflicts: According to diagnostic potential of the research ALL, JG, ES, MM, MJR, NM and JVT have applied for a PCT application to develop a clinical diagnostic kit. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JG MJR NM JMVT. Performed the experiments: ALL ES MS. Analyzed the data: JVT ALL. Contributed reagents/materials/analysis tools: JG MM NM JMVT. Wrote the paper: ALL JG JMVT. Oversaw experiments: MJR NM JMVT. Obtained funding: JG MM MJR NM. Critical review, manuscript edits and approval: ALL JG ES MM MS MJR NM JMVT.