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Research Article

The Immunosuppressant Protosappanin A Diminished Recipient T Cell Migration into Allograft via Inhibition of IP-10 in Rat Heart Transplant

  • Maomao Zhang,

    Affiliations: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Jieqiong He,

    Affiliations: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Jingbo Hou,

    Affiliations: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Jian Wu,

    Affiliations: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Meng Sun,

    Affiliation: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China

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  • Jinjin Cui,

    Affiliations: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Jiangtian Tian,

    Affiliation: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China

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  • Miaomiao Jiang,

    Affiliation: Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Bo Yu mail

    yubodr@163.com

    Affiliations: The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China, Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

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  • Published: May 05, 2014
  • DOI: 10.1371/journal.pone.0096138

About the Authors

Maomao Zhang, Jieqiong He, Jingbo Hou, Jian Wu, Meng Sun, Jinjin Cui, Jiangtian Tian, Bo Yu
The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, Heilongjiang Province, China
Maomao Zhang, Jieqiong He, Jingbo Hou, Jian Wu, Jinjin Cui, Miaomiao Jiang, Bo Yu
Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China

Corresponding Author

Email: yubodr@163.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMZ BY. Performed the experiments: JBH JJC JQH MMJ. Analyzed the data: JW JTT MS. Contributed reagents/materials/analysis tools: MMZ JJC. Wrote the paper: JBH MS.