About the Authors

Takashi Maejima

Contributed equally to this work with: Takashi Maejima, Tsuyoshi Inoue

Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

Tsuyoshi Inoue

Contributed equally to this work with: Takashi Maejima, Tsuyoshi Inoue

Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

Yasuharu Kanki

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Takahide Kohro

Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Guoliang Li

Affiliation Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

Yoshihiro Ohta

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Hiroshi Kimura

hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

Affiliation Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Mika Kobayashi

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Akashi Taguchi

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Shuichi Tsutsumi

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Hiroko Iwanari

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Shogo Yamamoto

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Hirofumi Aruga

Affiliation Thermo Fisher Scientific, South San Francisco, California, United States of America

Shoulian Dong

Affiliation Thermo Fisher Scientific, South San Francisco, California, United States of America

Junko F. Stevens

Affiliation Thermo Fisher Scientific, South San Francisco, California, United States of America

Huay Mei Poh

Affiliation Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

Kazuki Yamamoto

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Takeshi Kawamura

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Imari Mimura

Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

Jun-ichi Suehiro

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Akira Sugiyama

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Kiyomi Kaneki

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Haruki Shibata

Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

Yasunobu Yoshinaka

Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

Takeshi Doi

Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

Akimune Asanuma

Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

Sohei Tanabe

Affiliation Tokyo New Drug Research Laboratories, Kowa Company Ltd., Higashimurayama, Tokyo, Japan

Toshiya Tanaka

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Takashi Minami

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Takao Hamakubo

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Juro Sakai

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Naohito Nozaki

Affiliation Mab Institute Inc., North Advancement Center for Science & Technology, Sapporo, Hokkaido, Japan

Hiroyuki Aburatani

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Masaomi Nangaku

Affiliation Division of Nephrology and Endocrinology, The University of Tokyo School of Medicine, Bunkyo-ku, Tokyo, Japan

Xiaoan Ruan

Affiliation Genome Institute of Singapore, Singapore, Singapore

Hideyuki Tanabe

Affiliation Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa, Japan

Yijun Ruan

Affiliation Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, United States of America

Sigeo Ihara

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Akira Endo

Affiliation Biopharm Research Laboratories, Inc., Koganei, Tokyo, Japan

Tatsuhiko Kodama

hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

Affiliation Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan

Youichiro Wada

hkimura@fbs.osaka-u.ac.jp (HK); kodama@lsbm.org (TK); ywada-tky@umin.ac.jp (YW)

Affiliations Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan, Radioisotope Center, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Competing Interests

Hirofumi Aruga, Shoulian Dong and Junko Stevens are employees of Life Technologies, which supplied the materials for Chromosome Conformation Capture (3C) and qPCR assays. Takashi Maejima, Yasunobu Yoshinaka, Takeshi Doi, Akimune Asanuma and Sohei Tanabe are employees of Kowa Company Ltd., which supplied pitavastatin. Naohito Nozaki is employed by a commercial company - Mab Institute Inc. Akira Endo is employed by a commercial company - Biopharm Research Laboratories, Inc. These do not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: T. Maejima TI MN H. Aburatani YR AE T. Kodama YW. Performed the experiments: T. Maejima TI YK HK MK AT HI KY T. Kawamura KK NN HT. Analyzed the data: TI T. Kohro GL YO S. Tsutsumi SY HMP SI XR. Contributed reagents/materials/analysis tools: H. Aruga SD J. Stevens IM J. Suehiro AS HS YY TD AA S. Tanabe TT T. Minami TH J. Sakai. Wrote the paper: T. Maejima TI YW.