About the Authors

Bo Wang

Affiliations Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Jessica E. Nevins

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America

Zach Nadler

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America

Gadi Wollstein

wollsteing@upmc.edu

Affiliation Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America

Hiroshi Ishikawa

Affiliations Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Richard A. Bilonick

Affiliations Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Larry Kagemann

Affiliations Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Ian A. Sigal

Affiliations Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Ireneusz Grulkowski

Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Jonathan J. Liu

Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Martin Kraus

Affiliations Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America, Department of Computer Science, University of Erlangen-Nuremberg, Nuremberg, Germany

Chen D. Lu

Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Joachim Hornegger

Affiliation Department of Computer Science, University of Erlangen-Nuremberg, Nuremberg, Germany

James G. Fujimoto

Affiliation Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Joel S. Schuman

Affiliations Department of Ophthalmology, University of Pittsburgh Medical Center (UPMC) Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: Drs. Kraus and Hornegger receive royalties for intellectual property licensed by Massachusetts Institute of Technology to Optovue. Dr. Fujimoto hold stock options in Optovue. Drs. Fujimoto and Schuman receive royalties for intellectual property licensed by Massachusetts Institute of Technology and Massachusetts Eye & Ear Infirmary to Zeiss. This does not alter the authors' adherence to PLoS One policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BW ZN GW HI JSS. Performed the experiments: BW JEN ZN. Analyzed the data: BW ZN RAB. Contributed reagents/materials/analysis tools: HI IG JJL MK CDL JH JGF. Wrote the paper: BW ZN. Revising the manuscript critically for important intellectual content: GW HI LK IAS JSS. Final approval of the manuscript: GW HI JSS.