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Research Article

Post-Translational Decrease in Respiratory Chain Proteins in the Polg Mutator Mouse Brain

  • David N. Hauser,

    Affiliations: Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, Brown University/National Institutes of Health Graduate Partnership Program, Department of Neuroscience, Brown University, Providence, Rhode Island, United States of America

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  • Allissa A. Dillman,

    Affiliations: Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden

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  • Jinhui Ding,

    Affiliation: Computational Biology Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Yan Li,

    Affiliation: Protein/Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Mark R. Cookson mail

    Cookson@mail.nih.gov

    Affiliation: Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: April 10, 2014
  • DOI: 10.1371/journal.pone.0094646

About the Authors

David N. Hauser, Allissa A. Dillman, Mark R. Cookson
Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
David N. Hauser
Brown University/National Institutes of Health Graduate Partnership Program, Department of Neuroscience, Brown University, Providence, Rhode Island, United States of America
Allissa A. Dillman
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Jinhui Ding
Computational Biology Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
Yan Li
Protein/Peptide Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: Cookson@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DNH AAD YL MRC. Performed the experiments: DNH AAD YL. Analyzed the data: DNH AAD JD YL MRC. Contributed reagents/materials/analysis tools: DNH AAD JD YL MRC. Wrote the paper: DNH AAD YL MRC.