About the Authors

David Gfeller

Affiliations The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Swiss Institute of Bioinformatics, Quartier Sorge, Bâtiment Génopode, Lausanne, Switzerland

Andreas Ernst

Current address: Institute of Biochemistry II, Theodor-Stern-Kai 7, Goethe-University of Frankfurt, Frankfurt, Germany

Affiliation The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

Nick Jarvik

Affiliation The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

Sachdev S. Sidhu

Affiliations The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Gary D. Bader

gary.bader@utoronto.ca

Affiliations The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DG GDB. Performed the experiments: DG AE NJ. Analyzed the data: DG AE SSS GDB. Contributed reagents/materials/analysis tools: AE NJ. Wrote the paper: DG GDB.