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Research Article

Critical Importance of Long-Term Adherence to Care in HIV Infected Patients in the cART Era: New Insights from Pneumocystis jirovecii Pneumonia Cases over 2004–2011 in the FHDH-ANRS CO4 Cohort

  • Blandine Denis mail,

    bdenis@ccde.chups.jussieu.fr

    Affiliations: Inserm UMRS 1136, Paris, France, UPMC Univ Paris 06 UMRS 1136, Paris, France

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  • Marguerite Guiguet,

    Affiliations: Inserm UMRS 1136, Paris, France, UPMC Univ Paris 06 UMRS 1136, Paris, France

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  • Nathalie de Castro,

    Affiliations: Service de maladies infectieuses et tropicales, CHU Saint Louis, AP-HP, Paris, France, Université Paris Diderot, Paris, France

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  • Frédéric Mechaï,

    Affiliation: Service de maladies infectieuses et tropicales, CHU Avicenne AP-HP, Bobigny, France

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  • Matthieu Revest,

    Affiliation: Service de maladies infectieuses et tropicales, CHU Rennes, Rennes, France

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  • Aba Mahamat,

    Affiliations: Service de maladies infectieuses et tropicales, CHU Cayenne, Cayenne, France, EA 3595, Univ Antilles-Guyane, Cayenne, France

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  • Giovanna Melica Gregoire,

    Affiliations: Service de maladies infectieuses et tropicales, CHU Saint Louis, AP-HP, Paris, France, Université Paris Diderot, Paris, France

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  • Olivier Lortholary,

    Affiliations: CHU Necker-Enfants malades, AP-HP, Centre d'Infectiologie Necker Pasteur, Paris, France, Université Paris Descartes, Institut Imagine, Paris, France, Institut Pasteur, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France, CNRS URA 3012, Paris, France

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  • Dominique Costagliola

    Affiliations: Inserm UMRS 1136, Paris, France, UPMC Univ Paris 06 UMRS 1136, Paris, France

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  • Published: April 11, 2014
  • DOI: 10.1371/journal.pone.0094183

About the Authors

Blandine Denis, Marguerite Guiguet, Dominique Costagliola
Inserm UMRS 1136, Paris, France
Blandine Denis, Marguerite Guiguet, Dominique Costagliola
UPMC Univ Paris 06 UMRS 1136, Paris, France
Nathalie de Castro, Giovanna Melica Gregoire
Service de maladies infectieuses et tropicales, CHU Saint Louis, AP-HP, Paris, France
Nathalie de Castro, Giovanna Melica Gregoire
Université Paris Diderot, Paris, France
Frédéric Mechaï
Service de maladies infectieuses et tropicales, CHU Avicenne AP-HP, Bobigny, France
Matthieu Revest
Service de maladies infectieuses et tropicales, CHU Rennes, Rennes, France
Aba Mahamat
Service de maladies infectieuses et tropicales, CHU Cayenne, Cayenne, France
Aba Mahamat
EA 3595, Univ Antilles-Guyane, Cayenne, France
Olivier Lortholary
CHU Necker-Enfants malades, AP-HP, Centre d'Infectiologie Necker Pasteur, Paris, France
Olivier Lortholary
Université Paris Descartes, Institut Imagine, Paris, France
Olivier Lortholary
Institut Pasteur, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France
Olivier Lortholary
CNRS URA 3012, Paris, France

Corresponding Author

Email: bdenis@ccde.chups.jussieu.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BD MG OL DC. Analyzed the data: BD MG DC. Wrote the paper: BD MG NdC FM MR AM GMG OL DC. Has full access to all the data and takes responsibility for the integrity of the data and the accuracy of the data analysis: BD. Drafted the article: BD. Made substantial contributions to conception and design, acquisition of data, analysis, and interpretation of data: BD MG DC. Made substantial contributions to conception and design, and interpretation of data: OL. Made substantial contributions to acquisition and interpretation of data: NdC FM MR AM GMG. Critically revised the article for important intellectual content: BD MG NdC FM MR AM GMG OL DC. Provided final approval of the version to be published: BD MG NdC FM MR AM GMG OL DC.