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Research Article

Disruptions in Brain Networks of Older Fallers Are Associated with Subsequent Cognitive Decline: A 12-Month Prospective Exploratory Study

  • Chun Liang Hsu,

    Affiliations: Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada, Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, Center for Hip Health and Mobility, Vancouver, British Columbia, Canada

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  • Michelle W. Voss,

    Affiliations: Health, Brain, & Cognition Lab, University of Iowa, Iowa City, Iowa, United States of America, Department of Psychology, University of Iowa, Iowa City, Iowa, United States of America

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  • Todd C. Handy,

    Affiliations: Centre for Clinical Epidemiology and Evaluation, University of British Columbia & Vancouver Coastal Health Research Institute (VCHRI), Vancouver, British Columbia, Canada, Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Jennifer C. Davis,

    Affiliations: Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, Centre for Clinical Epidemiology and Evaluation, University of British Columbia & Vancouver Coastal Health Research Institute (VCHRI), Vancouver, British Columbia, Canada

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  • Lindsay S. Nagamatsu,

    Affiliations: Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, Center for Hip Health and Mobility, Vancouver, British Columbia, Canada, Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada

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  • Alison Chan,

    Affiliations: Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada, Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, Center for Hip Health and Mobility, Vancouver, British Columbia, Canada

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  • Niousha Bolandzadeh,

    Affiliations: Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada, Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, Center for Hip Health and Mobility, Vancouver, British Columbia, Canada

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  • Teresa Liu-Ambrose mail

    tlambrose@exchange.ubc.ca

    Affiliations: Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada, Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada, Center for Hip Health and Mobility, Vancouver, British Columbia, Canada

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  • Published: April 03, 2014
  • DOI: 10.1371/journal.pone.0093673

About the Authors

Chun Liang Hsu, Lindsay S. Nagamatsu, Alison Chan, Niousha Bolandzadeh, Teresa Liu-Ambrose
Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada
Chun Liang Hsu, Jennifer C. Davis, Alison Chan, Niousha Bolandzadeh, Teresa Liu-Ambrose
Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada
Chun Liang Hsu, Jennifer C. Davis, Lindsay S. Nagamatsu, Alison Chan, Niousha Bolandzadeh, Teresa Liu-Ambrose
Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
Chun Liang Hsu, Lindsay S. Nagamatsu, Alison Chan, Niousha Bolandzadeh, Teresa Liu-Ambrose
Center for Hip Health and Mobility, Vancouver, British Columbia, Canada
Michelle W. Voss
Health, Brain, & Cognition Lab, University of Iowa, Iowa City, Iowa, United States of America
Michelle W. Voss
Department of Psychology, University of Iowa, Iowa City, Iowa, United States of America
Todd C. Handy, Jennifer C. Davis
Centre for Clinical Epidemiology and Evaluation, University of British Columbia & Vancouver Coastal Health Research Institute (VCHRI), Vancouver, British Columbia, Canada
Todd C. Handy, Lindsay S. Nagamatsu
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: tlambrose@exchange.ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CLH MWV TCH JCD LSN AC NB TLA. Performed the experiments: CLH MWV TCH JCD LSN AC NB TLA. Analyzed the data: CLH MWV TLA. Contributed reagents/materials/analysis tools: MWV TLA. Wrote the paper: CLH MWV TCH JCD LSN AC NB TLA. Seed-based functional connectivity analysis technique: MWV.