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Research Article

Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats

  • Toshiki Doi,

    Affiliation: Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan

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  • Shigehiro Doi,

    Affiliation: Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan

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  • Ayumu Nakashima,

    Affiliation: Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan

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  • Toshinori Ueno,

    Affiliation: Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan

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  • Yukio Yokoyama,

    Affiliation: Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan

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  • Nobuoki Kohno,

    Affiliation: Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

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  • Takao Masaki mail

    masakit@hiroshima-u.ac.jp

    Affiliation: Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan

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  • Published: April 02, 2014
  • DOI: 10.1371/journal.pone.0093513

About the Authors

Toshiki Doi, Shigehiro Doi, Ayumu Nakashima, Toshinori Ueno, Yukio Yokoyama, Takao Masaki
Department of Nephrology, Hiroshima University Hospital, Hiroshima, Japan
Nobuoki Kohno
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

Corresponding Author

Email: masakit@hiroshima-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TD SD TM. Performed the experiments: TD AN TU. Analyzed the data: TD SD YY. Contributed reagents/materials/analysis tools: NK TM. Wrote the paper: TD SD TM.