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Research Article

Overexpression of Nrf2 Protects against Microcystin-Induced Hepatotoxicity in Mice

  • Yuan-Fu Lu,

    Affiliations: University of Kansas Medical Center, Kansas City, Kansas, United States of America, Key Lab for Basic Pharmacology of Ministry of Education, Zunyi Medical College, Zunyi, China

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  • Jie Liu,

    Affiliations: University of Kansas Medical Center, Kansas City, Kansas, United States of America, Key Lab for Basic Pharmacology of Ministry of Education, Zunyi Medical College, Zunyi, China

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  • Kai Connie Wu,

    Affiliation: University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Qiang Qu,

    Affiliation: University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Fang Fan,

    Affiliation: Cytopathology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Curtis D. Klaassen mail

    curtisklaassenphd@gmail.com

    Affiliation: University of Kansas Medical Center, Kansas City, Kansas, United States of America

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  • Published: March 25, 2014
  • DOI: 10.1371/journal.pone.0093013

About the Authors

Yuan-Fu Lu, Jie Liu, Kai Connie Wu, Qiang Qu, Curtis D. Klaassen
University of Kansas Medical Center, Kansas City, Kansas, United States of America
Yuan-Fu Lu, Jie Liu
Key Lab for Basic Pharmacology of Ministry of Education, Zunyi Medical College, Zunyi, China
Fang Fan
Cytopathology, University of Kansas Medical Center, Kansas City, Kansas, United States of America

Corresponding Author

Email: curtisklaassenphd@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL Y-FL CDK. Performed the experiments: Y-FL QQ KCW JL. Analyzed the data: Y-FL JL FF. Contributed reagents/materials/analysis tools: CDK Y-FL. Wrote the paper: JL CDK Y-FL.