Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe

Ming Yue; Li Zeng; Amanpreet Singh; Yongjie Xu

doi:10.1371/journal.pone.0092936

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Open Access

Peer-reviewed

Research Article

Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe

Ming Yue,

Current address: Division of Biological Sciences, University of Chicago, Chicago, Illinois, United States of America

Affiliation Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Li Zeng,

Affiliation Department of Pediatrics, The 1st Affiliated Hospital of Zhengzhou University, Zhengzhou City, China
⨯
Amanpreet Singh,

Affiliation Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Yongjie Xu

* E-mail: yong-jie.xu@wright.edu

Affiliation Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯

Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe

Ming Yue,
Li Zeng,
Amanpreet Singh,
Yongjie Xu

Published: March 24, 2014
https://doi.org/10.1371/journal.pone.0092936

About the Authors

Ming Yue

Current address: Division of Biological Sciences, University of Chicago, Chicago, Illinois, United States of America

Affiliation Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America

Li Zeng

Affiliation Department of Pediatrics, The 1st Affiliated Hospital of Zhengzhou University, Zhengzhou City, China

Amanpreet Singh

Affiliation Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America

Yongjie Xu

* E-mail: yong-jie.xu@wright.edu

Affiliation Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MY YJX. Performed the experiments: MY LZ AS YJX. Analyzed the data: MY YJX. Contributed reagents/materials/analysis tools: MY YJX. Wrote the paper: MY YJX.

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Point mutation
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Phosphorylation
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DNA replication
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Schizosaccharomyces pombe
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DNA damage
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Mutation
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Deletion mutation
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Thiamine
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