Molecular Archaeology of Flaviviridae Untranslated Regions: Duplicated RNA Structures in the Replication Enhancer of Flaviviruses and Pestiviruses Emerged via Convergent Evolution

Dmitri J. Gritsun; Ian M. Jones; Ernest A. Gould; Tamara S. Gritsun

doi:10.1371/journal.pone.0092056

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Peer-reviewed

Research Article

Molecular Archaeology of Flaviviridae Untranslated Regions: Duplicated RNA Structures in the Replication Enhancer of Flaviviruses and Pestiviruses Emerged via Convergent Evolution

Dmitri J. Gritsun,

Affiliation School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom
⨯
Ian M. Jones,

Affiliation School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom
⨯
Ernest A. Gould,

Affiliation Unité des Virus Emergents, Faculté de Médecine Timone, Marseille, France
⨯
Tamara S. Gritsun

* E-mail: t.s.gritsun@reading.ac.uk

Affiliation School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom
⨯

Molecular Archaeology of Flaviviridae Untranslated Regions: Duplicated RNA Structures in the Replication Enhancer of Flaviviruses and Pestiviruses Emerged via Convergent Evolution

Dmitri J. Gritsun,
Ian M. Jones,
Ernest A. Gould,
Tamara S. Gritsun

Published: March 19, 2014
https://doi.org/10.1371/journal.pone.0092056

About the Authors

Dmitri J. Gritsun

Affiliation School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom

Ian M. Jones

Affiliation School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom

Ernest A. Gould

Affiliation Unité des Virus Emergents, Faculté de Médecine Timone, Marseille, France

Tamara S. Gritsun

* E-mail: t.s.gritsun@reading.ac.uk

Affiliation School of Biological Sciences, University of Reading, Whiteknights, Reading, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJG IMJ EAG TSG. Performed the experiments: DJG IMJ EAG TSG. Analyzed the data: DJG IMJ EAG TSG. Contributed reagents/materials/analysis tools: DJG IMJ EAG TSG. Wrote the paper: DJG IMJ EAG TSG.

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RNA structure
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Sequence alignment
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Flaviviruses
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Pestivirus
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RNA alignment
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Viral structure
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Mosquitoes
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Viral replication
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