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Research Article

Anti-Platelet Therapy with Clopidogrel Prevents Endothelial Dysfunction and Vascular Remodeling in Aortas from Hypertensive Rats

  • Fernanda R. Giachini mail,

    fernandagiachini@hotmail.com

    Affiliation: Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra do Garças, MT, Brazil

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  • Romulo Leite,

    Affiliation: School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG, Brazil

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  • David A. Osmond,

    Affiliation: Department of Physiology, Georgia Regents University, Augusta, Georgia, United States of America

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  • Victor V. Lima,

    Affiliation: Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra do Garças, MT, Brazil

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  • Edward W. Inscho,

    Affiliation: Department of Physiology, Georgia Regents University, Augusta, Georgia, United States of America

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  • R. Clinton Webb,

    Affiliation: Department of Physiology, Georgia Regents University, Augusta, Georgia, United States of America

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  • Rita C. Tostes

    Affiliation: Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil

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  • Published: March 17, 2014
  • DOI: 10.1371/journal.pone.0091890

About the Authors

Fernanda R. Giachini, Victor V. Lima
Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra do Garças, MT, Brazil
Romulo Leite
School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, MG, Brazil
David A. Osmond, Edward W. Inscho, R. Clinton Webb
Department of Physiology, Georgia Regents University, Augusta, Georgia, United States of America
Rita C. Tostes
Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil

Corresponding Author

Email: fernandagiachini@hotmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FRG RL EWI RCW RCT. Performed the experiments: FRG RL DAO VVL. Analyzed the data: FRG RL DAO VVL. Contributed reagents/materials/analysis tools: FRG RL DAO VVL EWI RCW RCT. Wrote the paper: FRG RL VVL EWI RCW RCT.