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Research Article

Study of Protein Haptenation by Amoxicillin Through the Use of a Biotinylated Antibiotic

  • Adriana Ariza,

    Affiliations: Department of Chemical and Physical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain, Research Laboratory Carlos Haya Hospital-IBIMA, Málaga, Spain

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  • Daniel Collado,

    Affiliations: Department of Organic Chemistry, University of Málaga, Malaga, Spain, BIONAND-Andalusian Centre for Nanomedicine and Biotechnology, Parque Tecnológico de Andalucía, Málaga, Spain

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  • Yolanda Vida,

    Affiliations: Department of Organic Chemistry, University of Málaga, Malaga, Spain, BIONAND-Andalusian Centre for Nanomedicine and Biotechnology, Parque Tecnológico de Andalucía, Málaga, Spain

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  • María I. Montañez,

    Affiliations: Research Laboratory Carlos Haya Hospital-IBIMA, Málaga, Spain, BIONAND-Andalusian Centre for Nanomedicine and Biotechnology, Parque Tecnológico de Andalucía, Málaga, Spain

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  • Ezequiel Pérez-Inestrosa,

    Affiliations: Department of Organic Chemistry, University of Málaga, Malaga, Spain, BIONAND-Andalusian Centre for Nanomedicine and Biotechnology, Parque Tecnológico de Andalucía, Málaga, Spain

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  • Miguel Blanca,

    Affiliation: Allergy Service, Hospital Carlos Haya, Málaga, Spain

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  • María José Torres,

    Affiliation: Research Laboratory Carlos Haya Hospital-IBIMA, Málaga, Spain

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  • F. Javier Cañada,

    Affiliation: Department of Chemical and Physical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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  • Dolores Pérez-Sala mail

    dperezsala@cib.csic.es

    Affiliation: Department of Chemical and Physical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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  • Published: March 03, 2014
  • DOI: 10.1371/journal.pone.0090891

About the Authors

Adriana Ariza, F. Javier Cañada, Dolores Pérez-Sala
Department of Chemical and Physical Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain
Adriana Ariza, María I. Montañez, María José Torres
Research Laboratory Carlos Haya Hospital-IBIMA, Málaga, Spain
Daniel Collado, Yolanda Vida, Ezequiel Pérez-Inestrosa
Department of Organic Chemistry, University of Málaga, Malaga, Spain
Daniel Collado, Yolanda Vida, María I. Montañez, Ezequiel Pérez-Inestrosa
BIONAND-Andalusian Centre for Nanomedicine and Biotechnology, Parque Tecnológico de Andalucía, Málaga, Spain
Miguel Blanca
Allergy Service, Hospital Carlos Haya, Málaga, Spain

Corresponding Author

Email: dperezsala@cib.csic.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DPS EPI MJT. Performed the experiments: AA DC YV MIM. Analyzed the data: DPS AA MIM EPI MJT FJC MB. Contributed reagents/materials/analysis tools: EPI MJT DC YV MB. Wrote the paper: DPS AA MJT MIM.