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Research Article

Progressive Volume Loss and White Matter Degeneration in Cstb-Deficient Mice: A Diffusion Tensor and Longitudinal Volumetry MRI Study

  • Otto Manninen mail,

    otto.manninen@helsinki.fi

    Affiliations: Folkhälsan Institute of Genetics, Helsinki, Finland, Department of Medical Genetics and Research Program's Unit Haartman Institute, University of Helsinki, Helsinki, Finland, Neuroscience Center, University of Helsinki, Helsinki, Finland

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  • Teemu Laitinen,

    Affiliation: Department of Neurobiology A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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  • Kimmo K. Lehtimäki,

    Affiliation: Department of Neurobiology A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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  • Saara Tegelberg,

    Affiliations: Folkhälsan Institute of Genetics, Helsinki, Finland, Department of Medical Genetics and Research Program's Unit Haartman Institute, University of Helsinki, Helsinki, Finland, Neuroscience Center, University of Helsinki, Helsinki, Finland

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  • Anna-Elina Lehesjoki,

    Affiliations: Folkhälsan Institute of Genetics, Helsinki, Finland, Department of Medical Genetics and Research Program's Unit Haartman Institute, University of Helsinki, Helsinki, Finland, Neuroscience Center, University of Helsinki, Helsinki, Finland

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  • Olli Gröhn,

    Affiliation: Department of Neurobiology A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

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  • Outi Kopra

    Affiliations: Folkhälsan Institute of Genetics, Helsinki, Finland, Department of Medical Genetics and Research Program's Unit Haartman Institute, University of Helsinki, Helsinki, Finland, Neuroscience Center, University of Helsinki, Helsinki, Finland

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.pone.0090709

About the Authors

Otto Manninen, Saara Tegelberg, Anna-Elina Lehesjoki, Outi Kopra
Folkhälsan Institute of Genetics, Helsinki, Finland
Otto Manninen, Saara Tegelberg, Anna-Elina Lehesjoki, Outi Kopra
Department of Medical Genetics and Research Program's Unit Haartman Institute, University of Helsinki, Helsinki, Finland
Otto Manninen, Saara Tegelberg, Anna-Elina Lehesjoki, Outi Kopra
Neuroscience Center, University of Helsinki, Helsinki, Finland
Teemu Laitinen, Kimmo K. Lehtimäki, Olli Gröhn
Department of Neurobiology A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Corresponding Author

Email: otto.manninen@helsinki.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OM AEL OG OK. Performed the experiments: OM TL KKL ST. Analyzed the data: OM TL KKL. Contributed reagents/materials/analysis tools: AEL OG KKL TL. Wrote the paper: OM TL KKL ST AEL OG OK.