About the Authors
- Hiroaki Matsushita
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Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Akiko Sano
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Affiliations Kyowa Hakko Kirin, Co., Ltd., Chiyoda-ku, Tokyo, Japan, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Hua Wu
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Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Jin-an Jiao
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Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Poothappillai Kasinathan
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Affiliations Trans Ova Genetics, Sioux Center, Iowa, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Eddie J. Sullivan
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* E-mail: eddie.sullivan@sanfordhealth.org (ES); zonda.wang@usu.edu (ZW)
Affiliations Sanford Applied Biosciences L.L.C., Sioux Falls, South Dakota, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Zhongde Wang
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* E-mail: eddie.sullivan@sanfordhealth.org (ES); zonda.wang@usu.edu (ZW)
Affiliations Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, United States of America, Hematech, Inc., Sioux Falls, South Dakota, United States of America
- Yoshimi Kuroiwa
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Affiliations Kyowa Hakko Kirin, Co., Ltd., Chiyoda-ku, Tokyo, Japan, Hematech, Inc., Sioux Falls, South Dakota, United States of America
Competing Interests
The authors have the following interests: The work contained in the manuscript resulted from paid employment of each of the authors and was funded by Hematech, Inc., a former company which no longer exists. The work contained in the manuscript now belongs to Sanford Applied Biosciences, a non-profit company owned by Sanford Health of Sioux Falls, South Dakota. Co-authors Hiroaki Matsushita, Hua Wu, Jin-an Jiao and Eddie J Sullivan declare their paid employment by Sanford Applied Biosciences. Co-author Poothappillai Kasinathan is employed by Trans Ova Genetics. Sanford Applied Biosciences is a paying customer of Trans Ova Genetics. Co-authors Akiko Sano and Yoshimi Kuroiwa are employed by Kyowa Hakko Kirin, Co., Ltd. The authors also have the following patent pending related to the work (“Complex Chromosome Engineering for Production of Human Antibodies in Transgenic Animals”, PCT No.: US2013053618). The authors have developed cattle for the production of antibodies, and have trademarked Tc (Transchromosomal) Bovine, a genetically engineered cattle, which would be considered a product of the company. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. There are no further patents, products in development, or marketed products to declare.
Author Contributions
Conceived and designed the experiments: HM AS ZW YK PK ES JJ HW. Performed the experiments: HM AS. Analyzed the data: HM AS HW YK JJ ES ZW. Contributed reagents/materials/analysis tools: ES YK. Wrote the paper: HM ZW YK ES HW.