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Research Article

Targeted Recombinant Fusion Proteins of IFNγ and Mimetic IFNγ with PDGFβR Bicyclic Peptide Inhibits Liver Fibrogenesis In Vivo

  • Ruchi Bansal mail,

    R.Bansal@utwente.nl

    Affiliations: Department of Controlled Drug Delivery (Targeted Therapeutics), MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands, Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands

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  • Jai Prakash,

    Affiliations: Department of Controlled Drug Delivery (Targeted Therapeutics), MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands, Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands

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  • Marieke De Ruiter,

    Affiliation: Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands

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  • Klaas Poelstra

    Affiliation: Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands

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  • Published: February 24, 2014
  • DOI: 10.1371/journal.pone.0089878

About the Authors

Ruchi Bansal, Jai Prakash
Department of Controlled Drug Delivery (Targeted Therapeutics), MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
Ruchi Bansal, Jai Prakash, Marieke De Ruiter, Klaas Poelstra
Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands

Corresponding Author

Email: R.Bansal@utwente.nl

Competing Interests

KP is scientific advisor and shareholder of BiOrion Technologies B.V., a company dedicated to the commercialization of drug carriers, including the carrier presented here. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RB JP KP. Performed the experiments: RB MDR. Analyzed the data: RB JP. Wrote the paper: RB JP KP.