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Research Article

Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification

  • Markus Buchhaupt equal contributor mail,

    equal contributor Contributed equally to this work with: Markus Buchhaupt, Sunny Sharma

    buchhaupt@dechema.de (MB); entian@bio.uni-frankfurt.de (KE)

    Affiliation: DECHEMA Research Institute, Biochemical Engineering, Frankfurt am Main, Germany

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  • Sunny Sharma equal contributor,

    equal contributor Contributed equally to this work with: Markus Buchhaupt, Sunny Sharma

    Affiliation: Institute for Molecular Biosciences, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Stefanie Kellner,

    Affiliation: Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

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  • Stefanie Oswald,

    Affiliation: Institute for Molecular Biosciences, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Melanie Paetzold,

    Affiliation: DECHEMA Research Institute, Biochemical Engineering, Frankfurt am Main, Germany

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  • Christian Peifer,

    Affiliation: Institute for Molecular Biosciences, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Peter Watzinger,

    Affiliation: Institute for Molecular Biosciences, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Jens Schrader,

    Affiliation: DECHEMA Research Institute, Biochemical Engineering, Frankfurt am Main, Germany

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  • Mark Helm,

    Affiliation: Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

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  • Karl-Dieter Entian mail

    buchhaupt@dechema.de (MB); entian@bio.uni-frankfurt.de (KE)

    Affiliation: Institute for Molecular Biosciences, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Published: February 28, 2014
  • DOI: 10.1371/journal.pone.0089640

About the Authors

Markus Buchhaupt, Melanie Paetzold, Jens Schrader
DECHEMA Research Institute, Biochemical Engineering, Frankfurt am Main, Germany
Sunny Sharma, Stefanie Oswald, Christian Peifer, Peter Watzinger, Karl-Dieter Entian
Institute for Molecular Biosciences, Johann-Wolfgang Goethe University, Frankfurt am Main, Germany
Stefanie Kellner, Mark Helm
Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB KDE JS MH. Performed the experiments: MB SO MP CP PW SK SS. Analyzed the data: MB SO MP CP PW SK SS. Contributed reagents/materials/analysis tools: SO CP PW SK SS. Wrote the paper: MB SS SK KDE.