Disruption of Fyn SH3 Domain Interaction with a Proline-Rich Motif in Liver Kinase B1 Results in Activation of AMP-Activated Protein Kinase

Eijiro Yamada; Claire C. Bastie

doi:10.1371/journal.pone.0089604

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Open Access

Peer-reviewed

Research Article

Disruption of Fyn SH3 Domain Interaction with a Proline-Rich Motif in Liver Kinase B1 Results in Activation of AMP-Activated Protein Kinase

Eijiro Yamada,

Affiliations Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
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Claire C. Bastie

* E-mail: claire.bastie@einstein.yu.edu

Affiliations Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, Division Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom
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Disruption of Fyn SH3 Domain Interaction with a Proline-Rich Motif in Liver Kinase B1 Results in Activation of AMP-Activated Protein Kinase

Eijiro Yamada,
Claire C. Bastie

Published: February 25, 2014
https://doi.org/10.1371/journal.pone.0089604

About the Authors

Eijiro Yamada

Affiliations Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan

Claire C. Bastie

* E-mail: claire.bastie@einstein.yu.edu

Affiliations Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, Division Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CCB EY. Performed the experiments: CCB EY. Analyzed the data: CCB EY. Contributed reagents/materials/analysis tools: CCB. Wrote the paper: CCB.

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Phosphorylation
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Immunoprecipitation
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Skeletal muscles
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Tyrosine kinases
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Drug interactions
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HeLa cells
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Tyrosine
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Protein domains
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