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Research Article

Discovery of Selective Inhibitors of the Clostridium difficile Dehydroquinate Dehydratase

  • Kiira Ratia equal contributor,

    equal contributor Contributed equally to this work with: Kiira Ratia, Samuel H. Light, Aleksandar Antanasijevic

    Affiliation: Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, United States of America

    X
  • Samuel H. Light equal contributor,

    equal contributor Contributed equally to this work with: Kiira Ratia, Samuel H. Light, Aleksandar Antanasijevic

    Affiliations: Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

    X
  • Aleksandar Antanasijevic equal contributor,

    equal contributor Contributed equally to this work with: Kiira Ratia, Samuel H. Light, Aleksandar Antanasijevic

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

    X
  • Wayne F. Anderson,

    Affiliations: Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

    X
  • Michael Caffrey,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

    X
  • Arnon Lavie mail

    Lavie@uic.edu

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

    X
  • Published: February 21, 2014
  • DOI: 10.1371/journal.pone.0089356

About the Authors

Kiira Ratia
Research Resources Center, University of Illinois at Chicago, Chicago, Illinois, United States of America
Samuel H. Light, Wayne F. Anderson
Center for Structural Genomics of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
Samuel H. Light, Wayne F. Anderson
Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
Aleksandar Antanasijevic, Michael Caffrey, Arnon Lavie
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: Lavie@uic.edu

Competing Interests

The authors have declared that no competing interests exist

Author Contributions

Conceived and designed the experiments: AL KR SL AA WA MC. Performed the experiments: KR SHL AA. Analyzed the data: KR SHL AA MC AL. Wrote the paper: SHL AL.