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Research Article

Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

  • Nicolas Mercado,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Yasuo Kizawa,

    Affiliation: Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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  • Keitaro Ueda,

    Affiliation: Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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  • Yeping Xiong,

    Affiliation: Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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  • Genki Kimura,

    Affiliation: Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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  • Audric Moses,

    Affiliation: Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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  • Jonathan M. Curtis,

    Affiliation: Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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  • Kazuhiro Ito,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Peter J. Barnes mail

    p.j.barnes@imperial.ac.uk

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Published: February 05, 2014
  • DOI: 10.1371/journal.pone.0088168

About the Authors

Nicolas Mercado, Kazuhiro Ito, Peter J. Barnes
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
Yasuo Kizawa, Keitaro Ueda, Genki Kimura
Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan
Yeping Xiong, Audric Moses, Jonathan M. Curtis
Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

Corresponding Author

Email: p.j.barnes@imperial.ac.uk

Competing Interests

Co-author Dr. Kazuhiro Ito is a PLOS ONE Editorial Board member and this work was funded by Daiichi Sankyo. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NM YX YK KI. Performed the experiments: NM GK AM JC KI KU. Analyzed the data: NM YK KI. Contributed reagents/materials/analysis tools: GK JC KI PB. Wrote the paper: NM KI PB.