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Research Article

1H-NMR-Based Metabolic Analysis of Human Serum Reveals Novel Markers of Myocardial Energy Expenditure in Heart Failure Patients

  • Zhiyong Du equal contributor,

    equal contributor Contributed equally to this work with: Zhiyong Du, Anna Shen, Yuli Huang

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Anna Shen equal contributor,

    equal contributor Contributed equally to this work with: Zhiyong Du, Anna Shen, Yuli Huang

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Department of Cardiology, The Third Hospital of Southern Medical University, Guangzhou, China

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  • Yuli Huang equal contributor,

    equal contributor Contributed equally to this work with: Zhiyong Du, Anna Shen, Yuli Huang

    Affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China

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  • Liang Su,

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Wenyan Lai,

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Peng Wang,

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Zhibing Xie,

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Zhiquan Xie,

    Affiliation: Department of Cardiology, Guangzhou General Hospital of PLA, Guangzhou, China

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  • Qingchun Zeng,

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Hao Ren mail,

    renhao67@aliyun.com (HR); dinglixu@smu.edu.cn (DX)

    Affiliations: Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China, Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China

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  • Dingli Xu mail

    renhao67@aliyun.com (HR); dinglixu@smu.edu.cn (DX)

    Affiliations: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China, Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China

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  • Published: February 05, 2014
  • DOI: 10.1371/journal.pone.0088102

About the Authors

Zhiyong Du, Anna Shen, Yuli Huang, Liang Su, Wenyan Lai, Peng Wang, Zhibing Xie, Qingchun Zeng, Dingli Xu
Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Zhiyong Du, Liang Su, Wenyan Lai, Peng Wang, Zhibing Xie, Qingchun Zeng, Hao Ren, Dingli Xu
Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China
Anna Shen
Department of Cardiology, The Third Hospital of Southern Medical University, Guangzhou, China
Zhiquan Xie
Department of Cardiology, Guangzhou General Hospital of PLA, Guangzhou, China
Hao Ren
Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DX ZD. Performed the experiments: AS LS ZD PW Zhibing Xie YH Zhiquan Xie. Analyzed the data: ZD YH LS. Contributed reagents/materials/analysis tools: WL PW Zhibing Xie HR. Wrote the paper: YH ZD AS QZ. Obtained funding: DX. Study supervision: DX HR.