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Research Article

Measurement Errors in Polymerase Chain Reaction Are a Confounding Factor for a Correct Interpretation of 5-HTTLPR Polymorphism Effects on Lifelong Premature Ejaculation: A Critical Analysis of a Previously Published Meta-Analysis of Six Studies

  • Paddy K. C. Janssen,

    Affiliations: Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Department of Central Hospital Pharmacy, Viecuri Hospital Venlo, Venlo, The Netherlands

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  • Berend Olivier,

    Affiliations: Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Deptartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Aeilko H. Zwinderman,

    Affiliation: Department of Medical Statistics, Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Marcel D. Waldinger mail

    md@waldinger.demon.nl

    Affiliations: Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Outpatient Department of Neurosexology, HagaZiekenhuis, The Hague, The Netherlands, Private Practice, Amstelveen, The Netherlands

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  • Published: March 03, 2014
  • DOI: 10.1371/journal.pone.0088031

About the Authors

Paddy K. C. Janssen, Berend Olivier, Marcel D. Waldinger
Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Paddy K. C. Janssen
Department of Central Hospital Pharmacy, Viecuri Hospital Venlo, Venlo, The Netherlands
Berend Olivier
Deptartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
Aeilko H. Zwinderman
Department of Medical Statistics, Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Marcel D. Waldinger
Outpatient Department of Neurosexology, HagaZiekenhuis, The Hague, The Netherlands
Marcel D. Waldinger
Private Practice, Amstelveen, The Netherlands

Corresponding Author

Email: md@waldinger.demon.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PKCJ MDW. Performed the experiments: PKCJ. Analyzed the data: PKCJ AZ BO MDW. Contributed reagents/materials/analysis tools: PKCJ. Wrote the paper: PKCJ MDW BO AZ.