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Research Article

Homeodomain Transcription Factor Meis1 Is a Critical Regulator of Adult Bone Marrow Hematopoiesis

  • Reina Ariki,

    Affiliation: Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan

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  • Satoru Morikawa,

    Affiliation: Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

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  • Yo Mabuchi,

    Affiliation: Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

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  • Sadafumi Suzuki,

    Affiliation: Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

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  • Mayuka Nakatake,

    Affiliation: Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan

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  • Kentaro Yoshioka,

    Affiliation: Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan

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  • Shinya Hidano,

    Affiliation: Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan

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  • Hiromitsu Nakauchi,

    Affiliation: Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan

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  • Yumi Matsuzaki,

    Affiliation: Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

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  • Takuro Nakamura mail,

    takuro-ind@umin.net (TN); ryogoi@rs.noda.tus.ac.jp (RG)

    Affiliation: Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan

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  • Ryo Goitsuka mail

    takuro-ind@umin.net (TN); ryogoi@rs.noda.tus.ac.jp (RG)

    Affiliation: Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan

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  • Published: February 03, 2014
  • DOI: 10.1371/journal.pone.0087646

About the Authors

Reina Ariki, Kentaro Yoshioka, Shinya Hidano, Ryo Goitsuka
Division of Development and Aging, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan
Satoru Morikawa, Yo Mabuchi, Sadafumi Suzuki, Yumi Matsuzaki
Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
Mayuka Nakatake, Takuro Nakamura
Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan
Hiromitsu Nakauchi
Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan

Corresponding Authors

Competing Interests

The authors declare no competing financial interests.

Author Contributions

Conceived and designed the experiments: Y. Mattsuzaki TN RG. Performed the experiments: RA SM Y. Mabuchi SS MN KY SH. Contributed reagents/materials/analysis tools: HN. Wrote the paper: TN RG.