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Research Article

Massive Withdrawal Symptoms and Affective Vulnerability Are Associated with Variants of the CHRNA4 Gene in a Subgroup of Smokers

  • Judit Lazary mail,

    balazs.dome@meduniwien.ac.at (BD); lazaryjudit@gmail.com (JL)

    Affiliation: Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary

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  • Peter Dome,

    Affiliations: Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary, National Institute of Psychiatry and Addictions, Budapest, Hungary

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  • Iren Csala,

    Affiliations: Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary, Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary

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  • Gabor Kovacs,

    Affiliation: Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary

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  • Gabor Faludi,

    Affiliation: Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary

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  • Mari Kaunisto,

    Affiliations: Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Folkhälsan Institute of Genetics, Helsinki, Finland

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  • Balazs Dome mail

    balazs.dome@meduniwien.ac.at (BD); lazaryjudit@gmail.com (JL)

    Affiliations: Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary, Department of Thoracic Surgery, National Institute of Oncology, Budapest, Hungary, Translational Thoracic Oncology Lab, Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria

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  • Published: January 30, 2014
  • DOI: 10.1371/journal.pone.0087141

About the Authors

Judit Lazary, Peter Dome, Iren Csala, Gabor Faludi
Department of Clinical and Theoretical Mental Health, Semmelweis University, Budapest, Hungary
Peter Dome
National Institute of Psychiatry and Addictions, Budapest, Hungary
Iren Csala
Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary
Gabor Kovacs, Balazs Dome
Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary
Mari Kaunisto
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Mari Kaunisto
Folkhälsan Institute of Genetics, Helsinki, Finland
Balazs Dome
Department of Thoracic Surgery, National Institute of Oncology, Budapest, Hungary
Balazs Dome
Translational Thoracic Oncology Lab, Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GK IC GF. Performed the experiments: JL MK. Analyzed the data: JL MK PD. Contributed reagents/materials/analysis tools: GK BD JL PD. Wrote the paper: JL PD BD.