About the Authors

Janina M. Jeff

Affiliation Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, Vanderbilt University, Nashville, Tennessee, United States of America

Loren L. Armstrong

Affiliation Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Marylyn D. Ritchie

Affiliation Center for System Genomics, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

Joshua C. Denny

Affiliations Department of Medicine, Division of Clinical Pharmacology,Vanderbilt University, Nashville, Tennessee, United States of America, Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America

Abel N. Kho

Affiliation Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Melissa A. Basford

Affiliation Office of Personalized Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Wendy A. Wolf

Affiliation Division of Genetics, Children's Hospital Boston, Boston, Massachusetts, United States of America

Jennifer A. Pacheco

Affiliation Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Rongling Li

Affiliation Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, United States of America

Rex L. Chisholm

Affiliation Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Dan M. Roden

Affiliations Department of Medicine, Division of Clinical Pharmacology,Vanderbilt University, Nashville, Tennessee, United States of America, Office of Personalized Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America

M. Geoffrey Hayes

Affiliations Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Dana C. Crawford

crawford@chgr.mc.vanderbilt.edu

Affiliation Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Competing Interests

The authors have the following interests: Dr. Dana Crawford is a PLOS ONE Editorial Board member. This does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JMJ DCC. Performed the experiments: MAB WAW JAP. Analyzed the data: JMJ. Contributed reagents/materials/analysis tools: RLC MGH DMR LLA MDR ANK. Wrote the paper: JMJ MDR JCD DMR MGH DCC. Significantly edited manuscript: RL.