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Research Article

Chromosomal Copy Number Aberrations in Colorectal Metastases Resemble Their Primary Counterparts and Differences Are Typically Non-Recurrent

  • Leonie J. M. Mekenkamp equal contributor,

    equal contributor Contributed equally to this work with: Leonie J. M. Mekenkamp, Josien C. Haan, Iris D. Nagtegaal, Bauke Ylstra

    Affiliation: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Josien C. Haan equal contributor,

    equal contributor Contributed equally to this work with: Leonie J. M. Mekenkamp, Josien C. Haan, Iris D. Nagtegaal, Bauke Ylstra

    Affiliation: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

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  • Daniëlle Israeli,

    Affiliation: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

    X
  • Hendrik F. B. van Essen,

    Affiliation: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

    X
  • Jeroen R. Dijkstra,

    Affiliation: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Patricia van Cleef,

    Affiliation: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Cornelis J. A. Punt,

    Affiliation: Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands

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  • Gerrit A. Meijer,

    Affiliation: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

    X
  • Iris D. Nagtegaal equal contributor,

    equal contributor Contributed equally to this work with: Leonie J. M. Mekenkamp, Josien C. Haan, Iris D. Nagtegaal, Bauke Ylstra

    Affiliation: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

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  • Bauke Ylstra equal contributor mail

    equal contributor Contributed equally to this work with: Leonie J. M. Mekenkamp, Josien C. Haan, Iris D. Nagtegaal, Bauke Ylstra

    B.Ylstra@vumc.nl

    Affiliation: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

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  • Published: February 05, 2014
  • DOI: 10.1371/journal.pone.0086833

About the Authors

Leonie J. M. Mekenkamp, Jeroen R. Dijkstra, Patricia van Cleef, Iris D. Nagtegaal
Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Josien C. Haan, Daniëlle Israeli, Hendrik F. B. van Essen, Gerrit A. Meijer, Bauke Ylstra
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cornelis J. A. Punt
Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands

Corresponding Author

Email: B.Ylstra@vumc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LJMM JCH IDN BY. Performed the experiments: LJMM JCH DI HFvE JRD PvC. Analyzed the data: LJMM JCH IDN BY. Wrote the paper: LJMM JCH IDN BY. Editing the paper and had final approval of the submitted and published versions: BY LJMM JCH DI HFvE JRD PvC CJAP GAM IDN. Revised the manuscript critically: GAM CJAP.