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Research Article

Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice

  • Regan Roat,

    Affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Vandana Rao,

    Affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Nicolai M. Doliba,

    Affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Franz M. Matschinsky,

    Affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • John W. Tobias,

    Affiliation: Bioinformatics Group, Penn Molecular Profiling Facility, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Eden Garcia,

    Affiliation: Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

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  • Rexford S. Ahima,

    Affiliation: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Yumi Imai mail

    imaiy@evms.edu

    Affiliations: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

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  • Published: February 05, 2014
  • DOI: 10.1371/journal.pone.0086815

About the Authors

Regan Roat, Vandana Rao, Rexford S. Ahima, Yumi Imai
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Nicolai M. Doliba, Franz M. Matschinsky
Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
John W. Tobias
Bioinformatics Group, Penn Molecular Profiling Facility, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Eden Garcia, Yumi Imai
Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Corresponding Author

Email: imaiy@evms.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RA YI. Performed the experiments: RR VR ND EG YI. Analyzed the data: RR ND FM JT RA YI. Contributed reagents/materials/analysis tools: FM JT RA YI. Wrote the paper: ND FM JT RA YI.