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Research Article

Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models

  • Iveta Novakova,

    Affiliation: Department of Medicinal Chemistry, University of Vienna, Vienna, Austria

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  • Eva-Anne Subileau,

    Affiliation: Biopredic International, Rennes, France

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  • Stefan Toegel,

    Affiliation: Department of Orthopedics, Medical University Vienna, Vienna, Austria

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  • Daniela Gruber,

    Affiliation: Core Facility Cell Imaging and Ultrastructure Research, University of Vienna, Vienna, Austria

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  • Bodo Lachmann,

    Affiliation: Department of Medicinal Chemistry, University of Vienna, Vienna, Austria

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  • Ernst Urban,

    Affiliation: Department of Medicinal Chemistry, University of Vienna, Vienna, Austria

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  • Christophe Chesne,

    Affiliation: Biopredic International, Rennes, France

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  • Christian R. Noe,

    Affiliation: Department of Medicinal Chemistry, University of Vienna, Vienna, Austria

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  • Winfried Neuhaus mail

    winfried.neuhaus@univie.ac.at

    Affiliations: Department of Medicinal Chemistry, University of Vienna, Vienna, Austria, Department of Anesthesia and Critical Care, University Hospital Würzburg, Würzburg, Germany

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  • Published: January 23, 2014
  • DOI: 10.1371/journal.pone.0086806

About the Authors

Iveta Novakova, Bodo Lachmann, Ernst Urban, Christian R. Noe, Winfried Neuhaus
Department of Medicinal Chemistry, University of Vienna, Vienna, Austria
Eva-Anne Subileau, Christophe Chesne
Biopredic International, Rennes, France
Stefan Toegel
Department of Orthopedics, Medical University Vienna, Vienna, Austria
Daniela Gruber
Core Facility Cell Imaging and Ultrastructure Research, University of Vienna, Vienna, Austria
Winfried Neuhaus
Department of Anesthesia and Critical Care, University Hospital Würzburg, Würzburg, Germany

Corresponding Author

Email: winfried.neuhaus@univie.ac.at

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EAS CRN WN. Performed the experiments: IN EAS ST DG WN. Analyzed the data: IN ST DG BL WN. Contributed reagents/materials/analysis tools: EAS ST DG CC BL EU CRN. Wrote the paper: EAS ST WN. Obtained permission for use of cell line PBMEC/C1-2: CRN. Obtained permission for use of cell line ECV304: WN. Manuscript preparation: EAS ST DG CC UE BL WN.