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Research Article

Collagen XVI Induces Expression of MMP9 via Modulation of AP-1 Transcription Factors and Facilitates Invasion of Oral Squamous Cell Carcinoma

  • Konstanze B. Bedal,

    Affiliations: Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany, Center for Medical Biotechnology, BioPark I, Regensburg, Germany

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  • Susanne Grässel,

    Affiliations: Department of Orthopaedic Surgery, Experimental Orthopaedics, University Hospital Regensburg, Regensburg, Germany, Center for Medical Biotechnology, BioPark I, Regensburg, Germany

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  • Peter J. Oefner,

    Affiliation: Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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  • Joerg Reinders,

    Affiliation: Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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  • Torsten E. Reichert,

    Affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany

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  • Richard Bauer mail

    richard.bauer@klinik.uni-regensburg.de

    Affiliations: Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany, Center for Medical Biotechnology, BioPark I, Regensburg, Germany

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  • Published: January 23, 2014
  • DOI: 10.1371/journal.pone.0086777

About the Authors

Konstanze B. Bedal, Torsten E. Reichert, Richard Bauer
Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany
Susanne Grässel
Department of Orthopaedic Surgery, Experimental Orthopaedics, University Hospital Regensburg, Regensburg, Germany
Konstanze B. Bedal, Susanne Grässel, Richard Bauer
Center for Medical Biotechnology, BioPark I, Regensburg, Germany
Peter J. Oefner, Joerg Reinders
Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

Corresponding Author

Email: richard.bauer@klinik.uni-regensburg.de

Competing Interests

Please note that the Center of Medical Biotechnology in Regensburg is not a commercial company. The center affiliates several departments, which belong to the University Hospital Regensburg : Dept. of Trauma surgery, Dept. of Orthopedic Surgery, Oral and Maxillofacial Surgery. These departments have no commercial intention and there are no competing interests.

Author Contributions

Conceived and designed the experiments: KBB RJB SG. Performed the experiments: KBB JR PJO. Analyzed the data: KBB RJB. Contributed reagents/materials/analysis tools: TER SG. Wrote the paper: RJB KBB SG JR.