About the Authors

Li Li

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Sashi Nadanaciva

Affiliation Compound Safety Prediction Group, Pfizer, Inc., Groton, Connecticut, United States of America

Zdenek Berger

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Wei Shen

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Katrina Paumier

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Joel Schwartz

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Kewa Mou

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Paula Loos

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Anthony J. Milici

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

John Dunlop

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Warren D. Hirst

warren.hirst@pfizer.com

Affiliation Neuroscience Research Unit, Pfizer, Inc., Cambridge, Massachusetts, United States of America

Competing Interests

All authors are employed by Pfizer Inc. and hold stock in Pfizer Inc. However, this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LL SN ZB WS KP AJM JD WDH. Performed the experiments: LL SN WS PL. Analyzed the data: LL SN ZB WS KP PL JS AJM JD WDH. Contributed reagents/materials/analysis tools: KM JS. Wrote the manuscript: LL SN ZB KP JD WDH.