Potential Reduction of Contralateral Second Breast-Cancer Risks by Prophylactic Mammary Irradiation: Validation in a Breast-Cancer-Prone Mouse Model

Igor Shuryak; Lubomir B. Smilenov; Norman J. Kleiman; David J. Brenner

doi:10.1371/journal.pone.0085795

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Open Access

Peer-reviewed

Research Article

Potential Reduction of Contralateral Second Breast-Cancer Risks by Prophylactic Mammary Irradiation: Validation in a Breast-Cancer-Prone Mouse Model

Igor Shuryak ,

* E-mail: is144@columbia.edu

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
⨯
Lubomir B. Smilenov,

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
⨯
Norman J. Kleiman,

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
⨯
David J. Brenner

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
⨯

Potential Reduction of Contralateral Second Breast-Cancer Risks by Prophylactic Mammary Irradiation: Validation in a Breast-Cancer-Prone Mouse Model

Igor Shuryak,
Lubomir B. Smilenov,
Norman J. Kleiman,
David J. Brenner

Published: December 20, 2013
https://doi.org/10.1371/journal.pone.0085795

About the Authors

Igor Shuryak

* E-mail: is144@columbia.edu

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America

Lubomir B. Smilenov

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America

Norman J. Kleiman

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America

David J. Brenner

Affiliation Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IS DJB. Performed the experiments: IS LBS NJK. Analyzed the data: IS. Contributed reagents/materials/analysis tools: LBS NJK. Wrote the manuscript: IS DJB.

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Breast cancer
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Cancer risk factors
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Mammary glands
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Radiation therapy
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Cancer epidemiology
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Mouse models
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Dose prediction methods
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Cloning
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