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Research Article

Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer

  • Bruna Victorasso Jardim-Perassi,

    Affiliations: Department of Biology, Universidade Estadual Paulista, São José do Rio Preto, São Paulo, Brazil, Laboratório de Investigação Molecular no Câncer, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil

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  • Ali S. Arbab,

    Affiliation: Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Lívia Carvalho Ferreira,

    Affiliations: Department of Biology, Universidade Estadual Paulista, São José do Rio Preto, São Paulo, Brazil, Laboratório de Investigação Molecular no Câncer, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil

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  • Thaiz Ferraz Borin,

    Affiliations: Laboratório de Investigação Molecular no Câncer, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil

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  • Nadimpalli R. S. Varma,

    Affiliation: Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • A. S. M. Iskander,

    Affiliation: Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Adarsh Shankar,

    Affiliation: Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Meser M. Ali,

    Affiliation: Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America

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  • Debora Aparecida Pires de Campos Zuccari mail

    debora.zuccari@famerp.br

    Affiliations: Laboratório de Investigação Molecular no Câncer, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil

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  • Published: January 09, 2014
  • DOI: 10.1371/journal.pone.0085311

About the Authors

Bruna Victorasso Jardim-Perassi, Lívia Carvalho Ferreira
Department of Biology, Universidade Estadual Paulista, São José do Rio Preto, São Paulo, Brazil
Bruna Victorasso Jardim-Perassi, Lívia Carvalho Ferreira, Thaiz Ferraz Borin, Debora Aparecida Pires de Campos Zuccari
Laboratório de Investigação Molecular no Câncer, Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
Ali S. Arbab, Nadimpalli R. S. Varma, A. S. M. Iskander, Adarsh Shankar, Meser M. Ali
Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, Michigan, United States of America
Thaiz Ferraz Borin, Debora Aparecida Pires de Campos Zuccari
Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil

Corresponding Author

Email: debora.zuccari@famerp.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BVJP ASA DAPCZ. Performed the experiments: BVJP ASA LCF TFB NRSV ASMI AS MMA. Analyzed the data: BVJP ASA LCF TFB NRSV AS. Contributed reagents/materials/analysis tools: MMA ASA DAPCZ. Wrote the paper: BVJP ASA DAPCZ.