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Research Article

Combinatorial PD-1 Blockade and CD137 Activation Has Therapeutic Efficacy in Murine Cancer Models and Synergizes with Cisplatin

  • Huafeng Wei equal contributor,

    equal contributor Contributed equally to this work with: Huafeng Wei, Likun Zhao

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Likun Zhao equal contributor,

    equal contributor Contributed equally to this work with: Huafeng Wei, Likun Zhao

    Affiliation: School of Bioscience and Bioengneering, South China University of Technology, Guangzhou, China

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  • Wei Li,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Kexing Fan,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Weizhu Qian,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Sheng Hou,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Hao Wang,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Min Dai,

    Affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Ingegerd Hellstrom,

    Affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Karl Erik Hellstrom,

    Affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Yajun Guo mail

    yguo_smmu@163.com

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Bioscience and Bioengneering, South China University of Technology, Guangzhou, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Published: December 19, 2013
  • DOI: 10.1371/journal.pone.0084927

About the Authors

Huafeng Wei, Wei Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Yajun Guo
International Joint Cancer Institute, Second Military Medical University, Shanghai, China
Likun Zhao, Yajun Guo
School of Bioscience and Bioengneering, South China University of Technology, Guangzhou, China
Huafeng Wei, Wei Li, Kexing Fan, Weizhu Qian, Sheng Hou, Hao Wang, Yajun Guo
School of Pharmacy, Liaocheng University, Liaocheng, China
Min Dai, Ingegerd Hellstrom, Karl Erik Hellstrom
Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: yguo_smmu@163.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HFW YJG KEH IH. Performed the experiments: HFW LKZ. Analyzed the data: HFW YJG KEH IH. Contributed reagents/materials/analysis tools: WL KXF WZQ SH HW MD. Wrote the manuscript: HFW YJG KEH IH.