About the Authors

Luping Zhou

lupingz@uow.edu.au

Affiliations CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia, Department of Computer Science and Software Engineering, University of Wollongong, Wollongong, Australia

Olivier Salvado

Affiliation CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia

Vincent Dore

Affiliation CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia

Pierrick Bourgeat

Affiliation CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia

Parnesh Raniga

Affiliation CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia

S. Lance Macaulay

Affiliation CSIRO Preventative-Health National Research Flagship, Parkville, Australia

David Ames

Affiliations National Ageing Research Institute, Parkville, Australia, Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Parkville, Australia

Colin L. Masters

Affiliation Mental Health Research Institute/Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia

Kathryn A. Ellis

Affiliations Mental Health Research Institute/Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia, Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Parkville, Australia

Victor L. Villemagne

Affiliation Department of Nuclear Medicine and Centre for PET, Austin Hospital, Heidelberg, Australia

Christopher C. Rowe

Affiliation Department of Nuclear Medicine and Centre for PET, Austin Hospital, Heidelberg, Australia

Jurgen Fripp

Affiliation CSIRO Preventative Health Flagship, CSIRO Computational Informatics, The Australian e-Health Research Centre, Herston, Australia

AIBL Research Group

Membership of the IPTc Taskforce is provided in the Acknowledgments.

Competing Interests

Luping Zhou, Olivier Salvado, Vincent Dore, Pierrick Bourgeat, Victor L. Villemagne, Christopher C. Rowe, Jurgen Fripp might be listed as co-inventor in a patent that has been lodged describing a technology using techniques described in this manuscript. The authors' patent application name is: Method and apparatus for the assessment of medical images. The patent application number is: PCT/AU2012/001536. More information could be found from this link: http://www.google.com/patents/WO2013086580A1?cl=en CogState Ltd. (http://cogstate.com/), Hollywood Private Hospital (http://www.hollywood.ramsayhealth.com.au/) and Sir Charles Gardner Hospital (http://www.scgh.health.wa.gov.au/) have contributed to the financial support of AIBL study through the partnership with the Science and Industry Endowment Fund (SIEF http://www.sief.org.au/). Pfizer International (http://www.pfizer.com.au/default.aspx) has contributed financial support to AIBL to assist with analysis of blood samples and to further the AIBL research program. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: LZ JF OS VD PB PR VLV CCR. Performed the experiments: LZ VD. Analyzed the data: LZ JF OS VD PB PR VLV CCR. Contributed reagents/materials/analysis tools: SLM DA CLM KAE VLV CCR. Wrote the paper: LZ JF OS PB VLV.