About the Authors
- Mengjin Liu
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Affiliations Department of Nutritional Sciences, FrieslandCampina, Amersfoort, The Netherlands, Centre for Molecular and Biomolecular Informatics, Radboud University, Nijmegen, The Netherlands
- Bruno Bienfait
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Affiliation Molecular Networks GmbH, Erlangen, Germany
- Oliver Sacher
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Affiliation Molecular Networks GmbH, Erlangen, Germany
- Johann Gasteiger
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Affiliations Molecular Networks GmbH, Erlangen, Germany, Computer-Chemie-Centrum, University of Erlangen-Nürnberg, Erlangen, Germany
- Roland J. Siezen
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Affiliation Centre for Molecular and Biomolecular Informatics, Radboud University, Nijmegen, The Netherlands
- Arjen Nauta
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Affiliation Department of Nutritional Sciences, FrieslandCampina, Amersfoort, The Netherlands
- Jan M. W. Geurts
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* E-mail: jan.geurts@frieslandcampina.com
Affiliation Department of Nutritional Sciences, FrieslandCampina, Amersfoort, The Netherlands
Competing Interests
Bruno Bienfait and Oliver Sacher are employees of Molecular Networks GmbH owned and managed by Johann Gasteiger. All three persons had been involved in the development of a prototype version of the "Reverse Pathway Engineering" program used for the described study. Presently, no further development and no marketing of the software program is being done. Mengjin Liu, Arjen Nauta and Jan Geurts are employees of FrieslandCampina. All three persons have been involved in developing the "Reverse Pathway Engineering" approach and in the associated bioinformatics analyses. This does not alter the authors′ adherence to all PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JMWG. Performed the experiments: ML. Analyzed the data: ML BB OS JG RJS. Contributed reagents/materials/analysis tools: BB OS JG. Wrote the paper: ML AN JMWG.