About the Authors

Kimberly A. Walters

kimberly.walters02@nationwidechildrens.org

Affiliation Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America

Yungui Huang

Affiliation Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America

Marco Azaro

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Kathleen Tobin

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Thomas Lehner

Affiliation Genomics Research Branch, The National Institute of Mental Health, Bethesda, Maryland, United States of America

Linda M. Brzustowicz

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Veronica J. Vieland

Affiliation Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America

Competing Interests

Dr. Brzustowicz serves as a consultant for the Janssen Pharmaceutical Companies of Johnson & Johnson. All remaining authors report no competing interests. This does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TL LMB VJV. Performed the experiments: KAW YH MA KT TL LMB VJV. Analyzed the data: KAW YH MA KT TL LMB VJV. Contributed reagents/materials/analysis tools: KAW YH MA KT TL LMB VJV. Wrote the paper: KAW YH MA KT TL LMB VJV.