Molecular Mechanisms Underlying Antiproliferative and Differentiating Responses of Hepatocarcinoma Cells to Subthermal Electric Stimulation

María Luisa Hernández-Bule; María Ángeles Trillo; Alejandro Úbeda

doi:10.1371/journal.pone.0084636

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Open Access

Peer-reviewed

Research Article

Molecular Mechanisms Underlying Antiproliferative and Differentiating Responses of Hepatocarcinoma Cells to Subthermal Electric Stimulation

María Luisa Hernández-Bule ,

* E-mail: mluisa.hernandez@hrc.es

Affiliation Bioelectromagnetics Service, Ramón y Cajal Institute for Medical Research, Ramón y Cajal University Hospital, Madrid, Spain
⨯
María Ángeles Trillo,

Affiliation Bioelectromagnetics Service, Ramón y Cajal Institute for Medical Research, Ramón y Cajal University Hospital, Madrid, Spain
⨯
Alejandro Úbeda

Affiliation Bioelectromagnetics Service, Ramón y Cajal Institute for Medical Research, Ramón y Cajal University Hospital, Madrid, Spain
⨯

Molecular Mechanisms Underlying Antiproliferative and Differentiating Responses of Hepatocarcinoma Cells to Subthermal Electric Stimulation

María Luisa Hernández-Bule,
María Ángeles Trillo,
Alejandro Úbeda

Published: January 8, 2014
https://doi.org/10.1371/journal.pone.0084636

About the Authors

María Luisa Hernández-Bule

* E-mail: mluisa.hernandez@hrc.es

Affiliation Bioelectromagnetics Service, Ramón y Cajal Institute for Medical Research, Ramón y Cajal University Hospital, Madrid, Spain

María Ángeles Trillo

Affiliation Bioelectromagnetics Service, Ramón y Cajal Institute for Medical Research, Ramón y Cajal University Hospital, Madrid, Spain

Alejandro Úbeda

Affiliation Bioelectromagnetics Service, Ramón y Cajal Institute for Medical Research, Ramón y Cajal University Hospital, Madrid, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MLHB AÚ. Performed the experiments: MLHB. Analyzed the data: MLHB MÁT AÚ. Contributed reagents/materials/analysis tools: MLHB. Wrote the paper: MLHB MÁT AÚ.

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Apoptosis
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Albumins
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Cancer treatment
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Cell cycle and cell division
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Immunofluorescence
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Functional electrical stimulation
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Cell differentiation
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Cyclins
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