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Research Article

Xenograft Tumors Vascularized with Murine Blood Vessels May Overestimate the Effect of Anti-Tumor Drugs: A Pilot Study

  • Zhihong Dong,

    Affiliation: Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America

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  • Atsushi Imai,

    Affiliation: Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America

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  • Sudha Krishnamurthy,

    Affiliation: Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America

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  • Zhaocheng Zhang,

    Affiliation: Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America

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  • Benjamin D. Zeitlin,

    Affiliation: Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America

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  • Jacques E. Nör mail

    jenor@umich.edu

    Affiliations: Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America, Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, Michigan, United States of America, Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: December 31, 2013
  • DOI: 10.1371/journal.pone.0084236

About the Authors

Zhihong Dong, Atsushi Imai, Sudha Krishnamurthy, Zhaocheng Zhang, Benjamin D. Zeitlin, Jacques E. Nör
Angiogenesis Research Laboratory, Department of Restorative Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
Jacques E. Nör
Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, Michigan, United States of America
Jacques E. Nör
Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
Jacques E. Nör
Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: jenor@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZD AI SK JEN. Performed the experiments: ZD AI SK ZZ BDZ. Analyzed the data: ZD AI SK ZZ BDZ JEN. Wrote the paper: ZD AI SK ZZ BDZ JEN.