About the Authors

Wilson C. Fok

Affiliation Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Yidong Chen

Affiliations Department of Epidemiology & Biostatistics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Alex Bokov

Affiliations Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Epidemiology & Biostatistics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Yiqiang Zhang

Affiliations Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Adam B. Salmon

Affiliations Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Research Service and Geriatric Research Education and Clinical Center, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas, United States of America

Vivian Diaz

Affiliation Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

Martin Javors

Affiliation Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

William H. Wood 3rd

Affiliation National Institute on Aging, Baltimore, Maryland, United States of America

Yongqing Zhang

Affiliation National Institute on Aging, Baltimore, Maryland, United States of America

Kevin G. Becker

Affiliation National Institute on Aging, Baltimore, Maryland, United States of America

Viviana I. Pérez

Affiliation Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, United States of America

Arlan Richardson

richardsona@uthscsa.edu

Affiliations Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Research Service and Geriatric Research Education and Clinical Center, Audie Murphy VA Hospital (STVHCS), San Antonio, Texas, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts. AR holds stock in and is on the board of directors for Rapamycin Holdings, Inc. and this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WF VP AR. Performed the experiments: WF YiZ AS VD WW. Analyzed the data: WF YC AB YiZ AS MJ YoZ KB. Wrote the paper: WF VP AR.