Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa

Adeseye Adekeye; Mohammad Haeri; Eduardo Solessio; Barry E. Knox

doi:10.1371/journal.pone.0083871

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Open Access

Peer-reviewed

Research Article

Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa

Adeseye Adekeye,

Affiliation Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology and Ophthalmology, Center for Vision Research, SUNY Upstate Medical University, Syracuse, New York, United States of America
⨯
Mohammad Haeri,

Affiliation Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology and Ophthalmology, Center for Vision Research, SUNY Upstate Medical University, Syracuse, New York, United States of America
⨯
Eduardo Solessio,

Affiliation Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology and Ophthalmology, Center for Vision Research, SUNY Upstate Medical University, Syracuse, New York, United States of America
⨯
Barry E. Knox

* E-mail: knoxb@upstate.edu

Affiliation Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology and Ophthalmology, Center for Vision Research, SUNY Upstate Medical University, Syracuse, New York, United States of America
⨯

Ablation of the Proapoptotic Genes Chop or Ask1 Does Not Prevent or Delay Loss of Visual Function in a P23H Transgenic Mouse Model of Retinitis Pigmentosa

Adeseye Adekeye,
Mohammad Haeri,
Eduardo Solessio,
Barry E. Knox

Published: February 11, 2014
https://doi.org/10.1371/journal.pone.0083871

About the Authors

Adeseye Adekeye

Affiliation Departments of Neuroscience & Physiology, Biochemistry & Molecular Biology and Ophthalmology, Center for Vision Research, SUNY Upstate Medical University, Syracuse, New York, United States of America

Mohammad Haeri

Eduardo Solessio

Barry E. Knox

* E-mail: knoxb@upstate.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AA MH BEK. Performed the experiments: AA. Analyzed the data: AA ES MH BEK. Contributed reagents/materials/analysis tools: AA ES MH BEK. Wrote the paper: AA BEK.

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Photoreceptors
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Retina
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Mouse models
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Retinal degeneration
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Genetically modified animals
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Cell death
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Light
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Retinitis pigmentosa
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