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Research Article

Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study

  • Omar Saeed Ali Al-Salahi equal contributor,

    equal contributor Contributed equally to this work with: Omar Saeed Ali Al-Salahi, Dan Ji, Aman Shah Abdul Majid

    Affiliation: Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM), Kepala Batas, Pulau Pinang, Malaysia

    X
  • Dan Ji equal contributor,

    equal contributor Contributed equally to this work with: Omar Saeed Ali Al-Salahi, Dan Ji, Aman Shah Abdul Majid

    Affiliation: Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Southwest Eye Hospital, Southwest Hospital, The Third Military Medical University, Chongqing, P.R. China

    X
  • Amin Malik Shah Abdul Majid,

    Affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

    X
  • Chan Kit-Lam,

    Affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia

    X
  • Wan Zaidah Abdullah,

    Affiliation: Haematology Department, School of Medical Sciences, USM, Kubang Kerian, Kelantan, Malaysia

    X
  • Abdelhamid Zaki,

    Affiliations: Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM), Kepala Batas, Pulau Pinang, Malaysia, Therapeutic Chemistry Department, National Research Centre, Cairo University, Dokki, Cairo, Egypt

    X
  • Shah Kamal Khan Jamal Din,

    Affiliation: OMF Surgery, Hospital Sultanah Bhiyah, Alor Setar, Kedah, Malaysia

    X
  • Narazah Mohd Yusoff mail,

    amanshah75@gmail.com (ASAM); narazah@amdi.usm.edu.my (NMY)

    Affiliation: Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM), Kepala Batas, Pulau Pinang, Malaysia

    X
  • Aman Shah Abdul Majid equal contributor mail

    equal contributor Contributed equally to this work with: Omar Saeed Ali Al-Salahi, Dan Ji, Aman Shah Abdul Majid

    amanshah75@gmail.com (ASAM); narazah@amdi.usm.edu.my (NMY)

    Affiliation: Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM), Kepala Batas, Pulau Pinang, Malaysia

    X
  • Published: January 07, 2014
  • DOI: 10.1371/journal.pone.0083818

About the Authors

Omar Saeed Ali Al-Salahi, Abdelhamid Zaki, Narazah Mohd Yusoff, Aman Shah Abdul Majid
Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia (USM), Kepala Batas, Pulau Pinang, Malaysia
Dan Ji
Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Southwest Eye Hospital, Southwest Hospital, The Third Military Medical University, Chongqing, P.R. China
Amin Malik Shah Abdul Majid, Chan Kit-Lam
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia
Wan Zaidah Abdullah
Haematology Department, School of Medical Sciences, USM, Kubang Kerian, Kelantan, Malaysia
Abdelhamid Zaki
Therapeutic Chemistry Department, National Research Centre, Cairo University, Dokki, Cairo, Egypt
Shah Kamal Khan Jamal Din
OMF Surgery, Hospital Sultanah Bhiyah, Alor Setar, Kedah, Malaysia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NMY ASAM DJ. Performed the experiments: OSAAS CKL WZA AZ. Analyzed the data: OSAAS DJ AMSAM ASAM. Contributed reagents/materials/analysis tools: NMY SKKJD. Wrote the paper: ASAM NMY.