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Research Article

A Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR-/- Mice

  • Christopher M. Depner,

    Affiliations: Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Maret G. Traber,

    Affiliations: Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Gerd Bobe,

    Affiliations: Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Elizabeth Kensicki,

    Affiliation: Metabolon, Inc., Durham, North Carolina, United States of America

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  • Kurt M. Bohren,

    Affiliation: United States Department of Agriculture, Agricultural Research Service, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Ginger Milne,

    Affiliation: Eicosanoid Core Laboratory, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Donald B. Jump mail

    Donald.Jump@oregonstate.edu

    Affiliations: Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America, Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

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  • Published: December 17, 2013
  • DOI: 10.1371/journal.pone.0083756

About the Authors

Christopher M. Depner, Maret G. Traber, Donald B. Jump
Nutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America
Gerd Bobe
Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, Oregon, United States of America
Christopher M. Depner, Maret G. Traber, Gerd Bobe, Donald B. Jump
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America
Elizabeth Kensicki
Metabolon, Inc., Durham, North Carolina, United States of America
Kurt M. Bohren
United States Department of Agriculture, Agricultural Research Service, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America
Ginger Milne
Eicosanoid Core Laboratory, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Corresponding Author

Email: Donald.Jump@oregonstate.edu

Competing Interests

As employees of Metabolon, Inc., EK and KMB have or have had affiliations with or financial involvement with Metabolon, Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CMD DBJ. Performed the experiments: CMD KMB EK GM DBJ. Analyzed the data: CMD GB KMB EK GM DBJ. Contributed reagents/materials/analysis tools: MGT GB KMB EK GM. Wrote the manuscript: CMD DBJ.