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Research Article

Enterococcus faecalis Subverts and Invades the Host Urothelium in Patients with Chronic Urinary Tract Infection

  • Harry Horsley,

    Affiliation: Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom

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  • James Malone-Lee,

    Affiliation: Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom

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  • David Holland,

    Affiliation: Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom

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  • Madeleine Tuz,

    Affiliation: Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom

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  • Andrew Hibbert,

    Affiliation: Imaging Suite, Royal Veterinary College, London, United Kingdom

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  • Michael Kelsey,

    Affiliation: Department of Microbiology, The Whittington Hospital NHS Trust, London, United Kingdom

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  • Anthony Kupelian,

    Affiliation: Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom

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  • Jennifer L. Rohn mail

    j.rohn@ucl.ac.uk

    Affiliation: Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom

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  • Published: December 10, 2013
  • DOI: 10.1371/journal.pone.0083637

About the Authors

Harry Horsley, James Malone-Lee, David Holland, Madeleine Tuz, Anthony Kupelian, Jennifer L. Rohn
Centre for Clinical Science and Technology, Research Department of Clinical Physiology, Division of Medicine, University College London, London, United Kingdom
Andrew Hibbert
Imaging Suite, Royal Veterinary College, London, United Kingdom
Michael Kelsey
Department of Microbiology, The Whittington Hospital NHS Trust, London, United Kingdom

Corresponding Author

Email: j.rohn@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HH JML JLR. Performed the experiments: HH JML JLR DH MT AK AH. Analyzed the data: HH JML JLR AH MK. Contributed reagents/materials/analysis tools: HH JML JLR AH MK. Wrote the manuscript: HH JML JLR AK.