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Research Article

A Trifluoromethyl Analogue of Celecoxib Exerts Beneficial Effects in Neuroinflammation

  • Alessandra Di Penta equal contributor,

    equal contributor Contributed equally to this work with: Alessandra Di Penta, Asako Chiba

    Affiliations: Neurogenomiks Laboratory, University of Basque Country (UPV/ EHU), Zamudio, Spain, Achucarro Basque Center for Neuroscience, Zamudio, Spain

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  • Asako Chiba equal contributor,

    equal contributor Contributed equally to this work with: Alessandra Di Penta, Asako Chiba

    Affiliations: Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

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  • Iraide Alloza,

    Affiliations: Neurogenomiks Laboratory, University of Basque Country (UPV/ EHU), Zamudio, Spain, Achucarro Basque Center for Neuroscience, Zamudio, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

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  • Ane Wyssenbach,

    Affiliation: Neurotek Laboratory, University of Basque Country (UPV/EHU), Zamudio, Spain

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  • Takashi Yamamura,

    Affiliation: Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

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  • Pablo Villoslada,

    Affiliation: Center of Neuroimmunology, Institute of Biomedical Research August Pi Sunyer (IDIBAPS) – Hospital Clinic of Barcelona, Barcelona, Spain

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  • Sachiko Miyake,

    Affiliations: Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

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  • Koen Vandenbroeck mail

    k.vandenbroeck@ikerbasque.org

    Affiliations: Neurogenomiks Laboratory, University of Basque Country (UPV/ EHU), Zamudio, Spain, Achucarro Basque Center for Neuroscience, Zamudio, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

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  • Published: December 11, 2013
  • DOI: 10.1371/journal.pone.0083119

About the Authors

Alessandra Di Penta, Iraide Alloza, Koen Vandenbroeck
Neurogenomiks Laboratory, University of Basque Country (UPV/ EHU), Zamudio, Spain
Alessandra Di Penta, Iraide Alloza, Koen Vandenbroeck
Achucarro Basque Center for Neuroscience, Zamudio, Spain
Asako Chiba, Takashi Yamamura, Sachiko Miyake
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Asako Chiba, Sachiko Miyake
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Iraide Alloza, Koen Vandenbroeck
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
Ane Wyssenbach
Neurotek Laboratory, University of Basque Country (UPV/EHU), Zamudio, Spain
Pablo Villoslada
Center of Neuroimmunology, Institute of Biomedical Research August Pi Sunyer (IDIBAPS) – Hospital Clinic of Barcelona, Barcelona, Spain

Corresponding Author

Email: k.vandenbroeck@ikerbasque.org

Competing Interests

The authors declare that Pablo Villoslada, as one of the co-authors of the manuscript, is a PLOS ONE Editorial Board. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Performed the experiments: AdP AC AW. Analyzed the data: AdP AC IA TY PV SM KV. Contributed reagents/materials/analysis tools: KV PV SM TY. Wrote the manuscript: AdP AC SM KV. Carried out the microscopy, molecular studies, organotypic cultures, EAE model and performed the statistical analysis: AdP AC. Performed astrocytes cultures: AW. Participated in the design and interpretation of the study: AdP AC IA PV SM TY KV. Read and approved the final manuscript: AdP AC IA AW PV SM TY KV.