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Research Article

Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety

  • Ruofeng Shang,

    Affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmacceutical Development, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

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  • Shengyu Wang,

    Affiliation: University Hospital of Gansu Traditional Chinese Medicine, Lanzhou, Gansu, China

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  • Ximing Xu,

    Affiliation: Université Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS, Paris, France

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  • Yunpeng Yi,

    Affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmacceutical Development, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

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  • Wenzhu Guo,

    Affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmacceutical Development, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

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  • YuLiu,

    Affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmacceutical Development, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

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  • Jianping Liang mail

    liangjp100@sina.com

    Affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmacceutical Development, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China

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  • Published: December 23, 2013
  • DOI: 10.1371/journal.pone.0082595

About the Authors

Ruofeng Shang, Yunpeng Yi, Wenzhu Guo, YuLiu, Jianping Liang
Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmacceutical Development, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics Science, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
Shengyu Wang
University Hospital of Gansu Traditional Chinese Medicine, Lanzhou, Gansu, China
Ximing Xu
Université Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS, Paris, France

Corresponding Author

Email: liangjp100@sina.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS SW JL. Performed the experiments: YY XX RS SW WG YL. Analyzed the data: SW XX YL. Wrote the paper: RS JL.