About the Authors

Li Tianjiao

Contributed equally to this work with: Li Tianjiao, Meng Xiansheng

Affiliation Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China

Wang Shuai

Affiliations Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China, Liaoning University of Traditional Chinese Medicine-Agilent Technologies Modern TCM and Multi-omics Research Collaboration Lab, Dalian, P. R. China

Meng Xiansheng

Contributed equally to this work with: Li Tianjiao, Meng Xiansheng

mxsvvv@163.com (MX); xiaorong-ran@aglient.com (XR)

Affiliations Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China, Liaoning University of Traditional Chinese Medicine-Agilent Technologies Modern TCM and Multi-omics Research Collaboration Lab, Dalian, P. R. China

Bao Yongrui

Affiliation Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China

Guan Shanshan

Affiliation Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China

Liu Bo

Affiliation Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China

Chen Lu

Affiliation Liaoning University of Traditional Chinese Medicine, Dalian, P. R. China

Wang Lei

Affiliations Agilent Technologies Co, Ltd., Beijing, P. R. China, Liaoning University of Traditional Chinese Medicine-Agilent Technologies Modern TCM and Multi-omics Research Collaboration Lab, Dalian, P. R. China

Ran Xiaorong

mxsvvv@163.com (MX); xiaorong-ran@aglient.com (XR)

Affiliations Agilent Technologies Co, Ltd., Beijing, P. R. China, Liaoning University of Traditional Chinese Medicine-Agilent Technologies Modern TCM and Multi-omics Research Collaboration Lab, Dalian, P. R. China

Competing Interests

The authors declare that their manuscript has no relationships with Agilent Technologies Co, Ltd., relating to employment, consultancy, patents, products in development or marketed products etc. This is part of a master∼s project and stands apart from any internal project. One of the corresponding authors, Xiaorong Ran, is employed by Agilent Technologies Co, Ltd., who helped in the study design, experiments and/or analyses. Lei Wang is also employed by Agilent Technologies Co, Ltd., who has supervised the study and helped in modifying the grammatical errors in the manuscript. The authors confirm that employment by Agilent Technologoies does not alter their adherence to any of the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LT WS MX. Performed the experiments: LT LB CL GS. Analyzed the data: LT WS BY LB CL GS. Contributed reagents/materials/analysis tools: RX WL. Wrote the paper: LT. Helped analyze the data: RX. Modified the grammatical errors in the manuscript: WL.