About the Authors

J. Jeffry Howbert

Contributed equally to this work with: J. Jeffry Howbert, Edward E. Patterson

Affiliation NeuroVista Corp., Seattle, Washington, United States of America

Edward E. Patterson

Contributed equally to this work with: J. Jeffry Howbert, Edward E. Patterson

Affiliation Veterinary Medical Center, University of Minnesota, St. Paul, Minnesota, United States of America

S. Matt Stead

Affiliation Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

Ben Brinkmann

Affiliation Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

Vincent Vasoli

Affiliation Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

Daniel Crepeau

Affiliation Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

Charles H. Vite

Affiliation School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Beverly Sturges

Affiliation Veterinary School, University of California Davis, Davis, California, United States of America

Vanessa Ruedebusch

Affiliation NeuroVista Corp., Seattle, Washington, United States of America

Jaideep Mavoori

Affiliation NeuroVista Corp., Seattle, Washington, United States of America

Kent Leyde

Affiliation NeuroVista Corp., Seattle, Washington, United States of America

W. Douglas Sheffield

Affiliation NeuroVista Corp., Seattle, Washington, United States of America

Brian Litt

Affiliation Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Gregory A. Worrell

Worrell.Gregory@mayo.edu

Affiliation Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota, United States of America

Competing Interests

Drs. Worrell, Litt, Vite, and Patterson have received research funding from NeuroVista Inc. for portions of this project. Drs. Worrell and Litt have served as paid consultants for NeuroVista. NeuroVista Inc. participated in the study design, analysis, decision to publish, and preparation of the manuscript. Drs. Howbert, Sheffield, Leyde, and Mavoori served as employees of NeuroVista during the period of the research activity. Drs. Worrell, Litt, and Mr. Leyde hold patents pertaining to seizure forecasting devices. Full details of the 45 patents are available upon request. The remaining authors have no additional conflicts of interest. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WDS JJH EEP KL BL GAW. Performed the experiments: JJH EEP CHV BS VR JM. Analyzed the data: JJH JM GAW SMS VV DC KL BL. Contributed reagents/materials/analysis tools: JJH EEP SMS VV DC CHV BS VR BB KL WDS GAW. Wrote the paper: JJH GAW BB.