About the Authors

Tetsuya Kawamura

Contributed equally to this work with: Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

Bryan Stephens

Contributed equally to this work with: Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin

Affiliations Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America, Biomedical Sciences Graduate Program, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Ling Qin

Contributed equally to this work with: Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

Xin Yin

Contributed equally to this work with: Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin

Affiliations Marine Drug Research Institute, Huaihai Institute of Technology, Lianyungang, China, Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America, Department of Medicine, Division of Pulmonary and Critical Care, University of California San Diego, La Jolla, California, United States of America

Michael R. Dores

Affiliation Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Thomas H. Smith

Affiliations Biomedical Sciences Graduate Program, School of Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Neil Grimsey

Affiliation Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Ruben Abagyan

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

JoAnn Trejo

Affiliation Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Irina Kufareva

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

Mark M. Fuster

Affiliations Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America, Department of Medicine, Division of Pulmonary and Critical Care, University of California San Diego, La Jolla, California, United States of America

Catherina L. Salanga

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

Tracy M. Handel

thandel@ucsd.edu

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TK BS LQ XY CLS IK MMF TMH. Performed the experiments: TK BS LQ XY CLS IK. Analyzed the data: TK BS LQ XY CLS IK MRD NG THS MMF TMH. Contributed reagents/materials/analysis tools: TK BS LQ XY CLS IK MRD NG THS RA JT MMF TMH. Wrote the paper: TK BS LQ XY CLS MMF TMH.