About the Authors

Keith R. Edwards

Contributed equally to this work with: Keith R. Edwards, Jaya Goyal

Affiliations Multiple Sclerosis Center of NE New York, Latham, New York, United States of America, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Jaya Goyal

Contributed equally to this work with: Keith R. Edwards, Jaya Goyal

Affiliation Department of Translational Medicine, Biogen Idec, Cambridge, Massachusetts, United States of America

Tatiana Plavina

Affiliation Department of Translational Medicine, Biogen Idec, Cambridge, Massachusetts, United States of America

Julie Czerkowicz

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Susan Goelz

Affiliation Department of Neurology Clinical Development, Biogen Idec, Cambridge, Massachusetts, United States of America

Ann Ranger

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Diego Cadavid

Affiliation Department of Neurology Clinical Development, Biogen Idec, Cambridge, Massachusetts, United States of America

Jeffrey L. Browning

browninj@bu.edu

Current address: Department of Microbiology and Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA

Affiliation Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, United States of America

Competing Interests

Authors, except for Dr. K. Edwards, are or were (JB) employees of Biogen Idec and this study was funded by Biogen Idec. Laurie Stephen at RBM provided development support for the multiplex used in this study. There are no patents, products in development or marketed products to declare. These interests do not alter the authors' adherence to all the PLOS ONE polices on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KE AR TP JG DC JB SG. Performed the experiments: KE JG TP AR JC. Analyzed the data: AR JC TP JG JB KE. Contributed reagents/materials/analysis tools: TP JG. Wrote the manuscript: JB DC JG.